Microsoft Research just released Sho, a marriage of .NET and Python. I would try it out, but I need to upgrade before I can run it.
Valve is giving away the Portal 2 soundtrack on the Portal website. You should go get it, for science. Portal 2 Soundtrack
An ebook, Think Stats: Probability and Statistics for Programmers, teaches statistics through hands on programming oriented exercises. You can find a data set used in the book here.
One of those really simple puzzle games. I suppose part of the puzzle is figuring out how to play, since I didn't see any clear directions. My best score so far is 7. Gimme Friction Baby h/t The Fourth Checkraise